Research Division of Functional Genomics
Functional genomics is a field of molecular biology that attempts to make use of the vast wealth of data produced by genomic and transcriptomic projects (such as genome sequencing projects and RNA-seq) to describe gene (and protein) functions and interactions.
Currently the Taipale group is the only member of the Research Division of Functional Genomics, and this group focuses on understanding the information encoded in the human genome through analysing the sequence-specific binding of transcription factors (TFs) to unmodified and epigenetically modified DNA using multiple different methods. Despite the extensive knowledge of transcription factor binding preferences, reading the regulatory code remains a challenge. To address this, they use in-vivo approaches, ChIP-seq, RNA-seq, active TF identification (ATI) and in vitro approaches to map binding specificities of TFs by HT-SELEX.
High-throughput studies of transcription factor binding specificities in human cancer cells.
Division of Functional Genomics
Scheeles väg 2
171 65 Solna