Research Division of Medical Inflammation Research
Humanity is suffering from many inflammatory diseases affecting specific tissues of the body. In rheumatoid arthritis, the joints of hands and feet are inflamed and destroyed, in multiple sclerosis the spinal chord and brain, in diabetes insulin-producing cells of the pancreas, in lupus the kidneys and in Sjögren's syndrome the salivary glands. In spite of very large research efforts we do not know why these diseases develop and we have no effective curative treatment for them.
At Medical Inflammation Research (MIR) we believe that it is necessary to take one step back to advance two steps forward. We need to analyse the basic mechanisms behind these diseases and for this work we need animal models. With the animal models we try to find out which genes are important for the human diseases and why the immune system suddenly starts to attack our own tissues. With the increased knowledge we hope to find new ways to predict the diseases, to develop new therapies to stop the disease process and optimally to find ways to completely abrogate development of disease in susceptible individuals.
Our main goals are:
- To identify the genes that control animal models for rheumatoid arthritis and multiple sclerosis.
- To use the animal models not only for understanding the basic mechanism of autoimmune disease but also as models for developing new diagnostic, preventive and therapeutic strategies.
- To understand the role of MHC class II genes in explaining the immune specificity of autoimmune disease.
Division of Medical Inflammation Research
Department of Medical Biochemistry and Biophysics (MBB)
Scheeles väg 2, B2 Plan 4
SE-171 77 Stockholm
Fax: +46-8-524 877 50
Phone Central Lab: +46-8-524 877 15
Phone Central Lab: +46-8-524 863 37
Collaborations and Networks
KI Temacenter (Chronic Infammatory Diseases)
Joint ID - Joint ID is a scientific project funded by SSF with an aim to develop a new diagnostic test for RA patients.
- Rikard Holmdahl, Karolinska Institute, Stockholm (Co-ordinator)
- Jan Khilberg, Uppsala University, Uppsala
- Inger Gjetsson, Gotenborg University, Gotenborg
Center for Autoimmune Diseases
JointID-clinical treatment (Rikard Holmdahl, partner) - a network project funded by Science Research Council (VR) - A new unique diagnostic test for Rheumatoid Arthritis
Cancer Redox (Rikard Holmdahl, partner) - a network project funded by Knut och Alice Wallenbergs Stiftelsen (KAW) - Targeting redox pathways for improved cancer therapy
Be The Cure’ (BTCURE)
Southern Medical University, China