High impact publications

Denna sida på svenska

Each year, researchers at Karolinska Institutet publish approx. 4,700 papers with original results in peer-reviewed scientific journals. Here we list the most recent publications with one or several authors from KI in high impact journals (JIF 15 and above). 

171113
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression
Palazon A, Tyrakis PA, Macias D, Velica P, Rundqvist H, Fitzpatrick S, Vojnovic N, Phan AT, Loman N, Hedenfalk I, Hatschek T, Lövrot J, Foukakis T, Goldrath AW, Bergh J, Johnson RS
Cancer Cell (2017) Online 13 November. Article.
On KI News: Harder for T cells to fight cancer in absence of VEGF-A

171109
20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years
Pan H, Gray R, Braybrooke J, Davies C, Taylor C, McGale P, Peto R, Pritchard KI, Bergh J, Dowsett M, Hayes. DF
NEJM (2017) Online 9 November. Original Article
On KI News: Breast cancer recurrence risk lingers longer than expected

171103
Fractional exhaled nitric oxide as a predictor of response to inhaled corticosteroids in patients with non-specific respiratory symptoms and insignificant bronchodilator reversibility: a randomised controlled trial
Price D, Buhl R, Chan A, Freeman D et al.
The Lancet Respiratory Medicine (2017) Online 3 November. Article in press.

171101
Incidence and Treatment of Patients Diagnosed With Inflammatory Bowel Diseases at 60 Years or Older in Sweden
Everhov ÅH, Halfvarson J, Myrelid P, Sachs MC, Nordenvall C, Söderling J, Ekbom A, Neovius M, Ludvigsson JF, Askling J, Olén O
Gastroenterology (2017) Online 1 November. Article in Press.
On KI News: Older people with bowel disease receive older medicines

171030
24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial
Soininen H, Solomon A, Jelle Visser P, Hendrix SB, Blennow K, Kivipelto M, Hartmann T on behalf of the LipiDiDiet clinical study group.
Lancet Neurology (2017) Online 30 October. Article.

171030
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
Ferreira MA, Vonk JM, Baurecht H et al.
Nature Genetics (2017) Online 30 October. Letter.
On KI News: Asthma, hay fever and eczema share more than 100 genetic risk factors

171027
What constitutes the prefrontal cortex?
Marie Carlén
Science (2017) online 27 October. Review.

171025
Prevalence of cerebral palsy in Uganda: a population-based study
Kakooza-Mwesige A, Andrews C, Peterson S, Wabwire Mangen F, Eliasson AC, Forssberg H
Lancet Global Health (2017) Online 25 October. Article
On KI News: Cerebral palsy survey in Uganda fills knowledge gap

171025
Less dementia with oral anticoagulation in atrial fibrillation
Friberg L, Rosenqvist M
European Heart Journal (2017) Online 25 October. Article.
On KI News: Blood-thinning drugs linked to decreased dementia risk in patients with atrial fibrillation

171023
Stable high-sensitivity cardiac troponin T levels and outcomes in patients with chest pain
Roos A, Bandstein N, Lundbäck M, Hammarsten O, Ljung R, Holzmann MJ
JACC (2017) Online 23 October. Article.

171023
Deciphering lipid structures based on platform-independent decision rules
Hartler J, Triebl A, Ziegl A et al
Nature Methods (2017) Online 23 October. Brief Communication.

171017
Blood Transfusions From Previously Pregnant Women and MortalityInterpreting the Evidence
Cable RG, Edgren G
JAMA (2017) Online 17 October. Editorial.

171011
Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundström E, Pachnis V, Marklund U
Gaestroentology (2017) Online 11 October. Article in Press

171009
Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia
Li Z, Chen J, Yu H et al
Nature Genetics (2017) Online 9 Otctober. Article.

171006
The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing
Lein E, Borm LE, Linnarsson S
Science (2017) Online 6 October. Review.

171005
Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease
Eikelboom JW, Connolly SJ, Bosch J et al.
NEJM (2017) Online 5 October. Original Article.

171002
Risk of Cardiovascular Ischemic Events After Surgical Castration and Gonadotropin-Releasing Hormone Agonist Therapy for Prostate Cancer: A Nationwide Cohort Study
Chen DY,  See LC,  Liu JR,  Chuang CK, Pang ST, Hsieh IC, Wen MS, Chen TH, Lin YC, Liaw CC, Hsu CL, Chang JWC, Kuo CF, Huang  WK
JCO (2017) Online 2 October. Original Report.

170926
The Heritability of Autism Spectrum Disorder
Sandin S, Lichtenstein P, Kuja-Halkola R, Hultman C, Larsson H, Reichenberg A
JAMA (2017) Online 26 September. Research Letter.

170921
Bivalirudin versus Heparin Monotherapy in Myocardial Infarction
Erlinge D, Omerovic E, Fröbert O et al.
NEJM (2017) Online 21 September. Original Article.

170920
Childhood onset inflammatory bowel disease and risk of cancer: a Swedish nationwide cohort study 1964-2014
Olén O, Askling J, Sachs MC, Frumento P, Neovius M, Smedby KE, Ekbom A, Malmborg P, Ludvigsson JF
BMJ (2017) Online 20 September. Research.
On KI News: Inflammatory bowel disease in childhood associated with increased risk of cancer

170914
Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke
Søndergaard L, Kasner SE, Rhodes JF, Andersen G, Iversen HK, Nielsen-Kudsk JE, Settergren MSjöstrand C, Roine RO, Hildick-Smith D, Spence JD,  Thomassen L, the Gore REDUCE Clinical Study Investigators
NEJM (2017) Online 14 September. Original Article. 

170913
Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial
Holman RR, Coleman RL, Chan JCN et al
Lancet Diabetes & Endocrinology (2017) Online 13 September. Article.

170912
Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation
Riffelmacher T, Clarke A, Richter FC, Stranks A, Pandey S, Danielli S, Hublitz P, Yu Z, Johnson E, Schwerd T, McCullagh J, Uhlig H, Jacobsen SEW, Simon AK.
Immunity (2017) Online 12 September. Article.

170912
Association Between Laparoscopic Antireflux Surgery and Recurrence of Gastroesophageal Reflux
Maret-Ouda J, Wahlin K, El-Serag HB, Lagergren J
JAMA (2017) Online 12 September. Original Investigation.
On KI News: Relapse rare in young men after antireflux surgery

170828
Oxygen Therapy in Suspected Acute Myocardial Infarction
Hofmann R, James SK, Jernberg T et al.
NEJM (2017) Online 28 August. Original Article.
From KI News: Oxygen therapy has no effect on patients with suspected heart attack

170826
PCI Versus CABG in Patients With Type 1 Diabetes and Multivessel Disease
Nyström T, Sartipy U, Franzén S, Eliasson B, Gudbjörnsdottir S, Miftaraj M, Lagerqvist B, Svensson A-M, och Holzmann MJ.
JACC (2017) Online 26 August. Article.
On KI News: Coronary artery bypass surgery effective in patients with type 1 diabetes

170809
Notch Signaling in Development, Tissue Homeostasis, and Disease
Siebel C, Lendahl U
Physiological Reviews (2017) Online 9 August. Review. 

170808
Distrust in the End-Of-Life Care Provided to a Parent and Long-Term Negative Outcomes Among Bereaved Adolescents: A Population-Based Survey Study
Beernaert K, Kreicbergs U, Furst CJ, Nyberg T, Steineck G, Bylund-Grenklo T
Journal of Clinical Oncology (2017), Original Report.

170804
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
Alberts R, de Vries EMG, Goode EC et al.
Gut (2017) Online 4 August. Original Article.

170803
IgG Endopeptidase in Highly Sensitized Patients Undergoing Transplantation
Jordan SC, Lorant T, Choi J, et al, NEJM (2017), original article

170803
Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis
Birkeland KI, Jørgensen ME, Carstensen B et al, The Lancet Diabetes & Endocrinology (2017), article.

170801
Increased Total mtDNA Copy Number Cures Male Infertility Despite Unaltered mtDNA Mutation Load
Jiang M, Eino T, Kauppila S et al, Cell Metabolism (2017), short article

170728
Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health
Cervenka I, Agudelo LZ, Ruas JL, Science (2017) 28 July, review.

170726
Sequencing and de novo assembly of 150 genomes from Denmark as a population reference
Maretty L, Jensen JM, Petersen B, Hultman CM och Sullivan P et al. Nature (2017) online 26 July, letter.

170725
Association of genetic variants related to serum calcium levels with coronary artery disease and myocardial infarction
Larsson SC, Burgess S, Michaëlsson K, JAMA (2017) 25 July, original investigation.
KI News: Higher calcium levels and risk of coronary artery disease

170719
Antidepressants during pregnancy and autism in offspring: population based cohort study
Rai D, K Lee B, Dalman C, Newschaffer C, Lewis G, Magnusson C, BMJ, 2017, research article.

170718
Prosthetic valve endocarditis after surgical aortic valve replacement
Natalie Glaser, Veronica Jackson, Martin J. Holzmann, Anders Franco-Cereceda, Ulrik Sartipy, Circulation (2017) online 18 July. Correspondence
KI News: Fewer infections in mechanical heart valves

170717
Cardiomyocyte renewal in the human heart: insights from the fall-out
Lázár E, Sadek HA, Bergmann O
European Heart Journal (2017) Online 7 July. Clinical Review.

170717
Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder
T Lim E, Uddin M, De Rubeis S, Chan Y, S Kamumbu A, Zhang X, M D'Gama A, N Kim S, Sean Hill R, P Goldberg A, Poultney C, J Minshew N, Kushima I, Aleksic B, Ozaki N, Parellada M, Arango C, J Penzol M, Carracedo A, Kolevzon A, M Hultman C, A Weiss L, Fromer M, G Chiocchetti A, M Freitag C, Autism Sequencing Consortium, M Church G, W Scherer S, D Buxbaum J & A Walsh C, Nature Neuroscience (2017) Online 17 July, research article.

170717
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Rebecca Sims et al. Laura Fratiglioni, Caroline Graff, Lina Keller, Hakan Thonberg, Charlotte Forsell, Lena Lilius, Anne Kinhult-Stählbom, Nature Genetics, (2017) online 17 July. Article.

170717
Association analyses based on false discovery rate implicate new loci for coronary artery disease
Christopher P Nelson et al, Johan L M Björkegren, Nature Genetics (2017), online 17 July. Letter.

170714
Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data
Matsushita K, Ballew SH, Coresh J et al.
Lancet Diabetes and Endocrinology (2017). Online 14 July. Article. 

170712
Gonadotropin-releasing Hormone Agonists, Orchiectomy, and Risk of Cardiovascular Disease: Semi-ecologic, Nationwide, Population-based Study
Thomsen FB, Sandin F, Garmo H, Lissbrant IF, Ahlgren G, Van Hemelrijck M, Adolfsson J, Robinson D, Stattin P
European Urology (2017) Online 12 July. Article in press.

170710
Genotype–covariate interaction effects and the heritability of adult body mass index
Robinson MR, English G, Moser G et al.
Nature Genetics (2017) Online 10 July. Analysis.

170707 
Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla
Furlan A, Dyachuk V Kastriti ME Calvo-Enrique L,Abdo H, Hadjab S, Chontorotzea T, Akkuratova N, Usoskin D, Kamenev D, Petersen J, Sunadome K, Memic F, Marklund U, Fried K, Topilko P, Lallemend F, Kharchenko PV, Ernfors P, Adameyko I
Science (2017) Online 7 July. Research Article.

170629
Use of Molecular Tools to Identify Patients With Indolent Breast Cancers With Ultralow Risk Over 2 Decades
Esserman L, Yau C, Thompson C et al.
JAMA Oncology (2017) Online 29 June. Original Investigation.
On KI News: Test identifies breast cancer patients with very low risk of death

170627
Effect of Acupuncture and Clomiphene in Chinese Women With Polycystic Ovary Syndrome – A Randomized Clinical Trial
Wu X-K, Stener-Victorin E, Kuang H-Y et al.
JAMA (2017) Online 27 June. Original Investigation.
On KI News: Acupuncture does not increase fertility in women with PCOS

170622
Oesophageal cancer
Lagergren J, Smyth E, Cunningham D, Lagergren P
The Lancet (2017) Online 22 June. Seminar.

170619
Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains
Geisheker MR, Heymann G, Wang T et al.
Nature Neuroscience (2017) Online 19 June. Article.

170615
Structural Basis of Egg Coat-Sperm Recognition at Fertilization
Raj I, Al Hosseini HS, Dioguardi E, Nishimura K, Han L, Villa A, de Sanctis D, Jovine L
Cell (2017) Online 15 June. Article.
On KI News: 3D images show how sperm binds to the egg surface

170614
Risk of major congenital malformations in relation to maternal overweight and obesity severity: cohort study of 1.2 million singletons
Persson M, Cnattingius S, Villamor E, Söderling J, Pasternak B, Stephansson O, Neovius M
BMJ (2017) Online 14 June. Research.

170613
Time to Delivery of an Automated External Defibrillator Using a Drone for Simulated Out-of-Hospital Cardiac Arrests vs Emergency Medical Services
Claesson A, Bäckman A, Ringh M, Svensson L, Nordberg P, Djärv T, Hollenberg J
JAMA (2017) Online 13 June. Research Letter.
On KI News: Drones can increase survival from cardiac arrest

170612
Variant surface antigens of Plasmodium falciparum and their roles in severe malaria
Wahlgren M, Goel S, Akhouri RR
Nature Reviews Microbiology (2017) Online 12 June. Article Series.

170612
Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor
Litchfield K, Levy M, Orlando G
Nature Genetics (2017) Online 12 June. Letter.

170612
Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor
Wang Z, McGlynn KA, Rajpert-De Meyts E et al
Nature Genetics (2017) Online 12 June. Letter.

170607
Vaccine Priming is Restricted to Draining Lymph Nodes and Controlled by Adjuvant-Mediated Antigen Uptake
Liang F, Lindgren G, Sandgren KJ, Thompson EA, Francica JR, Seubert A, De Gregorio E, Barnett S, O’Hagan DT, Sullivan NJ, Koup RA, Seder RA, Loré K
Science Translational Medicine (2017) Online 7 June. Research Article.

170605
Engineered Cpf1 variants with altered PAM specificities
Gao L, Cox DBT, Yan WX, Manteiga JC, Schneider MW, YamanoT, Nishimasu H, Nureki O, Crosetto N, Zhang F
Nature Biotechnology (2017) Online 5 June. Letter.

170602
Association Between Proton Pump Inhibitor Use and Risk of Progression of Chronic Kidney Disease
Klatte DCF, Gasparini A, Xu H, de Deco P, Trevisan M, Johansson ALV, Wettermark B, Ärnlöv J, Janmaat CJ, Lindholm B, Dekker FW, Coresh J, Grams ME, Carrero JJ
Gastroenterology (2017) Online 2 June. Accepted Manuscript In Press.
On KI News: Heartburn medicine can increase risk of kidney disease

170601
MiR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes
Peng C, Li L, Zhang M-D, Bengtsson Gonzales C, Parisie M, Belfer I, Usoskin D, Abdo H, Furlan A, Häring M, Lallemend F, Harkany T, Diatchenko L, Hökfelt T, Hjerling-Leffler J, Ernfors P
Science (2017) Online 1 June. Report.
On KI News: Unexpected mechanism behind chronic nerve pain

170601
Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women
Klatt NR, Cheu R, Birse K, Zevin AS, Perner M, Noël-Romas L, Grobler A, Westmacott G, Xie IY, Butler J, Mansoor L,
McKinnon LR, Passmore JS, Abdool Karim Q,  Abdool Karim SS, Burgener AD
Science (2017) Online 1 June. Research Article.

170530
Outcomes in Patients With Chest Pain Discharged After Evaluation Using a High-Sensitivity Troponin T Assay
Nejatian A, Omstedt Å, Höijer J, Hansson LO, Djärv T, Eggers KM, Svensson P
JACC (2017) Online 30 May. Article.
On KI News: High-sensitivity assay gives more reassurance to chest pain patients

170530
Seattle Heart Failure and Proportional Risk Models Predict Benefit From Implantable Cardioverter-Defibrillators
Bilchick KC, Wang Y, Cheng A, Curtis JP, Dharmarajan K, Stukenborg GJ, Shadman R, Anand I, Lund LH, Dahlström U, Sartipy U, Maggioni A, Swedberg K, O'Conner C, Levy WC.
JACC (2017) Online 30 May. Article.

170522
Social Fear Learning: from Animal Models to Human Function
Debiec J, Olsson A
Trends in Congnitive Sciences (2017) Online 22 May. Review.

170522
Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues
Sugden WW, Meissner R, Aegerter-Wilmsen T, Tsaryk R, Leonard EV, Bussmann J, Hamm MJ, Herzog W, Jin Y, Jakobsson L, Denz C, Siekmann AF
Nature Cell Biology (2017) Online 22 May. Article.

170522
Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling
Jin Y, Muhl L, Burmakin M, Wang Y, Duchez A-C, Betsholtz C, Arthur HM, Jakobsson L
Nature Cell Biology (2017) Online 22 May. Article.
On KI News: New findings on formation and malformation of blood vessels

170522
Preterm birth and risk of Heart Failure Up to Early Adulthood
Carr H, Cnattingius S, Granath F, Ludvigsson JF, Edstedt Bonamy A-K
JACC (2017) Online 22 May. Article.
On KI News: Preterm birth linked to higher risk of heart failure

170522
Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
Sniekers S, Stringer S, Watanabe K et al.
Nature Genetics (2017) Online 22 May. Letter.

170519
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
Galluzzi L, Bravo-San Pedtro JM, Levine B, Green DR, Kroemer G
Nature Reviews Drug Discovery (2017) Online 19 May. Review.

170516
Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach
Martinez-Murillo P, Tran K, Guenaga J, Lindgren G, Àdori M, Feng Y, Phad GE, Vázquez Bernat N, Bale S, Ingale J, Dubrovskaya V, O’Dell S, Pramanik L, Spångberg M, Corcoran M, Loré K, Mascola JR, Wyatt RT, Karlsson Hedestam GB
Immunity (2017). Online 16 May. Article.

170515
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
Weiner DJ, Wigdor EM, Ripke S et al
Nature Genetics (2017) Online 15 May. Analysis.

170515
Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia
Giustacchini A, Thongjuea S, Barkas N et al.
Nature Medicine (2017) Online 15 May. Article.

170512
The changing prevalence and incidence of dementia over time — current evidence
Wu Y-T, Beiser AS, Breteler MB, Fratiglioni L et al.
Nature Reviews Neurology (2017) Online 12 May. Review.

170511
Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver
Minutti CM, Jackson-Jones LH, García-Fojeda B, Knipper JA, Sutherland TE, Logan N, Rinqvist E, Guillamat-Prats R, Ferenbach DA, Artigas A, Stamme C, Chroneos ZC, Zaiss DM, Casals C, Allen JE
Science (2017) Online 11 May. Report.

170511
A subcellular map of the human proteome
Thul PJ, Åkesson L, Wiking M
Science (2017) Online 11 May. Research Article.

170510
A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
Tammela T, Sanchez-Rivera FJ, Cetinbas NM et al.
Nature (2017) Online 10 May. Letter.

170510
Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants
Karnes JH, Bastarache L, Shaffer CM et al.
Science Translational Medicine (2017) Online 10 May. Research Article.

170505
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J
Science (2017) Online 5 May. Research Article.
On KI News: Scientists reveal how epigenetic changes in DNA are interpreted

170502
The limits of exercise physiology: From performance to health
Gabriel BM, Zierath JR
Cell Metabolism (2017) Online 2 May. Perspective.

170501
Sickness Absence and Disability Pension After Breast Cancer Diagnosis: A 5-Year Nationwide Cohort Study
Kvillemo P, Mittendorfer-Rutz E, Bränström R, Nilsson K, Alexanderson K
JCO (2017) Online 1 May. Original Reports.

170501
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
Roper J, Tammela T, Malli N et al.
Nature Biotechnology (2017) Online 1 May. Research Letter.

Information for KI researchers

Can’t find your article in the high impact publications list above? Please contact the Communications and Public Relations Office so that we can add your article to the list. Current list criterias are that article author-lists include at least one researcher from KI, and that articles – original findings or reviews – are published in journals with JIF 15 or above. 

More on the Staff web portal

Send information about your publication

Publication