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Sten Linnarsson

Professor

Visiting address : Scheeles väg 1, Sweden
Postal address : Department of Medical Biochemistry and Biophysics (MBB), C2, Sten Linnarssons group, , 171 77 Stockholm, Sweden
Delivery address : Scheeles väg 2, receptionen, Sweden

Publications

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model
Rivetti Di Val Cervo P, Romanov Ra, Spigolon G, Masini D, Martín-montañez E, Toledo Em, et al
Nature biotechnology 2017;35(5):444-452

Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses
Niklasson M, Maddalo G, Sramkova Z, Mutlu E, Wee S, Sekyrova P, et al
Cancer research 2017;77(7):1741-1752

Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes
Romanov Ra, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, et al
Nature neuroscience 2017;20(2):176-188

Single-cell mRNA isoform diversity in the mouse brain
Karlsson K, Linnarsson S
BMC genomics 2017;18(1):126-

A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease
Villaescusa Jc, Li B, Toledo Em, Rivetti Di Val Cervo P, Yang S, Stott Sr, et al
The EMBO journal 2016;35(18):1963-78

Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes
Fuzik J, Zeisel A, Máté Z, Calvigioni D, Yanagawa Y, Szabó G, et al
Nature biotechnology 2016;34(2):175-183

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells
La Manno G, Gyllborg D, Codeluppi S, Nishimura K, Salto C, Zeisel A, et al
Cell 2016;167(2):566-580.e19

NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis
Tervaniemi Mh, Katayama S, Skoog T, Siitonen Ha, Vuola J, Nuutila K, et al
Scientific reports 2016;6():22745-

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
Marques S, Zeisel A, Codeluppi S, Van Bruggen D, Mendanha Falcão A, Xiao L, et al
Science (New York, N.Y.) 2016;352(6291):1326-1329

Origin, fate and dynamics of macrophages at central nervous system interfaces
Goldmann T, Wieghofer P, Jordão Mj, Prutek F, Hagemeyer N, Frenzel K, et al
Nature immunology 2016;17(7):797-805

Single-cell genomics: coming of age
Linnarsson S, Teichmann Sa
Genome biology 2016;17():97-

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos
Petropoulos S, Edsgärd D, Reinius B, Deng Q, Panula Sp, Codeluppi S, et al
Cell 2016;165(4):1012-26

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity
Joost S, Zeisel A, Jacob T, Sun X, La Manno G, Lönnerberg P, et al
Cell systems 2016;3(3):221-237.e9

The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation
Jouhilahti Em, Madissoon E, Vesterlund L, Töhönen V, Krjutškov K, Plaza Reyes A, et al
Development (Cambridge, England) 2016;143(19):3459-3469

Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control
Furlan A, La Manno G, Lübke M, Häring M, Abdo H, Hochgerner H, et al
Nature neuroscience 2016;19(10):1331-40

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
Ståhl Pl, Salmén F, Vickovic S, Lundmark A, Navarro Jf, Magnusson J, et al
Science (New York, N.Y.) 2016;353(6294):78-82

Amplification-free sequencing of cell-free DNA for prenatal non-invasive diagnosis of chromosomal aberrations
Karlsson K, Sahlin E, Iwarsson E, Westgren M, Nordenskjöld M, Linnarsson S
Genomics 2015;105(3):150-8

A secretagogin locus of the mammalian hypothalamus controls stress hormone release
Romanov Ra, Alpar A, Zhang Md, Zeisel A, Calas A, Landry M, et al
EMBO JOURNAL 2015;34(1):36-54

Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Zeisel A, Muñoz-manchado Ab, Codeluppi S, Lönnerberg P, La Manno G, Juréus A, et al
Science (New York, N.Y.) 2015;347(6226):1138-42

Dynamics of Lgr6(+) Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis
Fullgrabe A, Joost S, Are A, Jacob T, Sivan U, Haegebarth A, et al
STEM CELL REPORTS 2015;5(5):843-55

Gene expression analysis of skin grafts and cultured keratinocytes using synthetic RNA normalization reveals insights into differentiation and growth control
Katayama S, Skoog T, Jouhilahti Em, Siitonen Ha, Nuutila K, Tervaniemi Mh, et al
BMC genomics 2015;16():476-

NEUROSCIENCE. A tree of the human brain
Linnarsson S
Science (New York, N.Y.) 2015;350(6256):37-

Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development
Töhönen V, Katayama S, Vesterlund L, Jouhilahti Em, Sheikhi M, Madissoon E, et al
Nature communications 2015;6():8207-

Reprogramming Roadblocks Are System Dependent
Chantzoura E, Skylaki S, Menendez S, Kim Si, Johnsson A, Linnarsson S, et al
Stem cell reports 2015;5(3):350-64

Rewired metabolism in drug-resistant leukemia cells: a metabolic switch hallmarked by reduced dependence on exogenous glutamine
Stäubert C, Bhuiyan H, Lindahl A, Broom Oj, Zhu Y, Islam S, et al
The Journal of biological chemistry 2015;290(13):8348-59

Sequencing Single Cells Reveals Sequential Stem Cell States
Linnarsson S
Cell stem cell 2015;17(3):251-2

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
Usoskin D, Furlan A, Islam S, Abdo H, Lonnerberg P, Lou D, et al
NATURE NEUROSCIENCE 2015;18(1):145-53

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo
Woll Ps, Kjällquist U, Chowdhury O, Doolittle H, Wedge Dc, Thongjuea S, et al
Cancer cell 2014;25(6):794-808

Quantitative single-cell RNA-seq with unique molecular identifiers
Islam S, Zeisel A, Joost S, La Manno G, Zajac P, Kasper M, et al
Nature methods 2014;11(2):163-6

Selective calcium sensitivity in immature glioma cancer stem cells
Wee S, Niklasson M, Marinescu Vd, Segerman A, Schmidt L, Hermansson A, et al
PloS one 2014;9(12):e115698-

Topographical transcriptome mapping of the mouse medial ganglionic eminence by spatially resolved RNA-seq
Zechel S, Zajac P, Lonnerberg P, Ibanez Cf, Linnarsson S
GENOME BIOLOGY 2014;15(10):486-

Base preferences in non-templated nucleotide incorporation by MMLV-derived reverse transcriptases
Zajac P, Islam S, Hochgerner H, Lönnerberg P, Linnarsson S
PloS one 2013;8(12):e85270-

Erg channel is critical in controlling cell volume during cell cycle in embryonic stem cells
Abdelhady S, Kitambi Ss, Lundin V, Aufschnaiter R, Sekyrova P, Sinha I, et al
PloS one 2013;8(8):e72409-

High-resolution analysis with novel cell-surface markers identifies routes to iPS cells
O'malley J, Skylaki S, Iwabuchi Ka, Chantzoura E, Ruetz T, Johnsson A, et al
NATURE 2013;499(7456):88-91

SAMstrt: statistical test for differential expression in single-cell transcriptome with spike-in normalization
Katayama S, Töhönen V, Linnarsson S, Kere J
Bioinformatics (Oxford, England) 2013;29(22):2943-5

Single-cell biology meeting marks rebirth of an old science
Linnarsson S
GENOME BIOLOGY 2013;14(4):305-

Single-cell sequencing-based technologies will revolutionize whole-organism science
Shapiro E, Biezuner T, Linnarsson S
NATURE REVIEWS GENETICS 2013;14(9):618-30

Counting absolute numbers of molecules using unique molecular identifiers
Kivioja T, Vaharautio A, Karlsson K, Bonke M, Enge M, Linnarsson S, et al
NATURE METHODS 2012;9(1):72-4

Highly multiplexed and strand-specific single-cell RNA 5 ' end sequencing
Islam S, Kjallquist U, Moliner A, Zajac P, Fan Jb, Lonnerberg P, et al
NATURE PROTOCOLS 2012;7(5):813-28

Highly Parallel Genome-Wide Expression Analysis of Single Mammalian Cells
Fan Jb, Chen J, April Cs, Fisher Js, Klotzle B, Bibikova M, et al
PLOS ONE 2012;7(2):e30794-

Magnetic sequencing
Linnarsson S
NATURE METHODS 2012;9(4):339-341

Positional differences of axon growth rates between sensory neurons encoded by Runx3
Lallemend F, Sterzenbach U, Hadjab-lallemend S, Aquino Jb, Castelo-branco G, Sinha I, et al
The EMBO journal 2012;31(18):3718-29

RNA-Seq Analysis Reveals Different Dynamics of Differentiation of Human Dermis- and Adipose-Derived Stromal Stem Cells
Jaager K, Islam S, Zajac P, Linnarsson S, Neuman T
PLOS ONE 2012;7(6):e38833-

Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq
Islam S, Kjallquist U, Moliner A, Zajac P, Fan Jb, Lonnerberg P, et al
GENOME RESEARCH 2011;21(7):1160-7

En masse in vitro functional profiling of the axonal mechanosensitivity of sensory neurons
Usoskin D, Zilberter M, Linnarsson S, Hjerling-leffler J, Uhlen P, Harkany T, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010;107(37):16336-41

Recent advances in DNA sequencing methods - general principles of sample preparation
Linnarsson S
EXPERIMENTAL CELL RESEARCH 2010;316(8):1339-43

Rapid genome sequencing with short universal tiling probes
Pihlak A, Bauren G, Hersoug E, Lonnerberg P, Metsis A, Linnarsson S
NATURE BIOTECHNOLOGY 2008;26(6):676-84

Whole-genome expression profiling through fragment display and combinatorial gene identification
Metsis A, Andersson U, Bauren G, Ernfors P, Lonnerberg P, Montelius A, et al
NUCLEIC ACIDS RESEARCH 2004;32(16):e127-

Activation by GDNF of a transcriptional program repressing neurite growth in dorsal root ganglia
Linnarsson S, Mikaels A, Baudet C, Ernfors P
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2001;98(25):14681-6

Cell death in regenerating populations of neurons in BDNF mutant mice
Linnarsson S, Willson Ca, Ernfors P
MOLECULAR BRAIN RESEARCH 2000;75(1):61-9

BDNF regulates Reelin expression and Cajal-Retzius cell development in the cerebral cortex
Ringstedt T, Linnarsson S, Wagner J, Lendahl U, Kokaia Z, Arenas E, et al
NEURON 1998;21(2):305-15

Learning deficit in BDNF mutant mice
Linnarsson S, Bjorklund A, Ernfors P
EUROPEAN JOURNAL OF NEUROSCIENCE 1997;9(12):2581-7

Prenatal and postnatal requirements of NT-3 for sympathetic neuroblast survival and innervation of specific targets
Elshamy Wm, Linnarsson S, Lee Kf, Jaenisch R, Ernfors P
DEVELOPMENT 1996;122(2):491-500

DEPENDENCE OF DEVELOPING GROUP IA AFFERENTS ON NEUROTROPHIN-3
Kucera J, Fan Gp, Jaenisch R, Linnarsson S, Ernfors P
JOURNAL OF COMPARATIVE NEUROLOGY 1995;363(2):307-20

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