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Forskare vid Karolinska Institutet publicerar ungefär 4 700 vetenskapliga artiklar med originalresultat om året. Här listas aktuella publikationer i högt rankade vetenskapliga tidskrifter (impaktfaktor 15 och uppåt) där KI-forskare medverkar.

Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells
Carrelha J, Meng Y, Kettyle LM, Luis TC, Norfo R, Alcolea V, Grasso F, Gambardella A, Grover A, Högstrand K, Lord AM, Sanjuan-Pla A, Woll PS, Nerlov C, Jacobsen SEW
Nature (2018) Online 3 January. Letter.

An OPR 3-independent pathway uses 4,5-didehydrojasmonate for jasmonate synthesis
Chini A , Monte I , Zamarreño AM, Hamberg M, Lassueur S, Reymond P , Weiss S, Stintzi A, Schaller A,  Porzel A, García-Mina JM,  Solano R.
Nature Chemical Biology(2018) Online 1 January, Article.

Multi-trait analysis of genome-wide association summary statistics using
Turley P, Walters RK,  Maghzian O et al.
Nature Genetics (2018) Online 1 January, Article.

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Demenais F, Margaritte-Jeannin P,  Barnes KC et al.
Nature Genetics (2017) Online 22 December. Article.

Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation
Marty FM, Ljungman P, Chemaly RF et al.
NEJM (2017) Online 21 December. Original Article.

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner
Thion MS, Low D, Silvin A et al.
Cell (2017) Online 21 December. Article.

Our Gut Microbiome: The Evolving Inner Self
Kundu P, Blacher E, Elinav E, Pettersson S
Cell (2017) Online 14 December. Review.

Association Between Methylphenidate and Amphetamine Use in Pregnancy and Risk of Congenital MalformationsA Cohort Study From the International Pregnancy Safety Study Consortium
Huybrechts KF, Bröms G, Brix Christensen L et al.
JAMA Psychiatry (2017) Online 13 December. Original Investigation.

Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials
Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
The Lancet Oncology (2017) Online 11 December. Article.
Kommentar: Neoadjuvant chemotherapy in breast cancer: more than just downsizing

Modifiable pathways in Alzheimer’s disease: Mendelian randomisation analysis
Larsson SC, Traylor M, Malik R, Dichgans M, Burgess S, Markus HS; for the CoSTREAM Consortium, on behalf of the International Genomics of Alzheimer’s Project.
BMJ (2017) Online 7 December. Research.
På KI Nyheter: Nya belägg för att lång utbildning minskar risken för alzheimer

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
Skrott Z, Mistrik M, Kaae Andersen K et al.
Nature (2017) Online 6 December. Article.
På KI Nyheter: Antabus dödar cancerceller

An interactive framework for whole-brain maps at cellular resolution
Fürth D, Vaissière T, Tzortzi O, Xuan Y, Märtin A, Lazaridis I, Spigolon G, Fisone G, Tomer R, Deisseroth K, Carlén M, Miller CA, Rumbaugh G, Meletis K
Nature Neuroscience (2017) Online 4 December. Technical Report.

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia
Jansen WJ et al
JAMA Psychiatry (2017) Online 29 November. Original Investigation

Pembrolizumab is effective for drug-resistant gestational trophoblastic neoplasia
Ghorani E, Kaur B, Fisher RA, Short D, Joneborg U, Carlson JW, Akarca A, Marafioti T, Quezada SA, Sarwar N, Seckl MJ
The Lancet (2017) Online 25 November. Article.

An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression
Palazon A, Tyrakis PA, Macias D, Velica P, Rundqvist H, Fitzpatrick S, Vojnovic N, Phan AT, Loman N, Hedenfalk I, Hatschek T, Lövrot J, Foukakis T, Goldrath AW, Bergh J, Johnson RS
Cancer Cell (2017) Online 13 November. Article.
På KI Nyheter: Svårare för T-celler att bekämpa cancer om VEGF-A saknas

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years
Pan H, Gray R, Braybrooke J, Davies C, Taylor C, McGale P, Peto R, Pritchard KI, Bergh J, Dowsett M, Hayes. DF
NEJM (2017) Online 9 November. Original Article
På KI Nyheter: Oväntat långvarig risk för återfall i bröstcancer

Fractional exhaled nitric oxide as a predictor of response to inhaled corticosteroids in patients with non-specific respiratory symptoms and insignificant bronchodilator reversibility: a randomised controlled trial
Price D, Buhl R, Chan A, Freeman D et al.
The Lancet Respiratory Medicine (2017) Online 3 November. Article in press.

Incidence and Treatment of Patients Diagnosed With Inflammatory Bowel Diseases at 60 Years or Older in Sweden
Everhov ÅH, Halfvarson J, Myrelid P, Sachs MC, Nordenvall C, Söderling J, Ekbom A, Neovius M, Ludvigsson JF, Askling J, Olén O
Gastroenterology (2017) Online 1 November. Article in Press.
På KI Nyheter: Äldre tarmsjuka får äldre mediciner

24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial
Soininen H, Solomon A, Jelle Visser P, Hendrix SB, Blennow K, Kivipelto M, Hartmann T on behalf of the LipiDiDiet clinical study group.
Lancet Neurology (2017) Online 30 October. Article.

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
Ferreira MA, Vonk JM, Baurecht H et al.
Nature Genetics (2017) Online 30 October. Letter.
På KI Nyheter: Många gemensamma gener bakom astma, hösnuva och eksem

What constitutes the prefrontal cortex?
Marie Carlén
Science (2017) online 27 October. Review.

Prevalence of cerebral palsy in Uganda: a population-based study
Kakooza-Mwesige A, Andrews C, Peterson S, Wabwire Mangen F, Eliasson AC, Forssberg H
Lancet Global Health (2017) Online 25 October. Article.
På KI Nyheter: Stor kartläggning av cerebral pares i Uganda minskar kunskapsluckor

Less dementia with oral anticoagulation in atrial fibrillation
Friberg L, Rosenqvist M
European Heart Journal (2017) Online 25 October. Article.
På KI Nyheter: Blodförtunnande läkemedel kopplas till minskad demensrisk vid förmaksflimmer

Stable high-sensitivity cardiac troponin T levels and outcomes in patients with chest pain
Roos A, Bandstein N, Lundbäck M, Hammarsten O, Ljung R, Holzmann MJ
JACC (2017) Online 23 October. Article
På KI Nyheter: Troponin är förknippat med förhöjd risk att dö

Deciphering lipid structures based on platform-independent decision rules
Hartler J, Triebl A, Ziegl A et al
Nature Methods (2017) Online 23 October. Brief Communication.

Blood Transfusions From Previously Pregnant Women and MortalityInterpreting the Evidence
Cable RG, Edgren G
JAMA (2017) Online 17 October. Editorial.

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundström E, Pachnis V, Marklund U
Gaestroentology (2017) Online 11 October. Article in Press.

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia
Li Z, Chen J, Yu H et al
Nature Genetics (2017) Online 9 Otctober. Article.

The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing
Lein E, Borm LE, Linnarsson S
Science (2017) Online 6 October. Review.

Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease
Eikelboom JW, Connolly SJ, Bosch J et al.
NEJM (2017) Online 5 October. Original Article.

Risk of Cardiovascular Ischemic Events After Surgical Castration and Gonadotropin-Releasing Hormone Agonist Therapy for Prostate Cancer: A Nationwide Cohort Study
Chen DY,  See LC,  Liu JR,  Chuang CK, Pang ST, Hsieh IC, Wen MS, Chen TH, Lin YC, Liaw CC, Hsu CL, Chang JWC, Kuo CF, Huang  WK
JCO (2017) Online 2 October. Original Report.

The Heritability of Autism Spectrum Disorder
Sandin S, Lichtenstein P, Kuja-Halkola R, Hultman C, Larsson H, Reichenberg A
JAMA (2017) Online 26 September. Research Letter.

Bivalirudin versus Heparin Monotherapy in Myocardial Infarction
Erlinge D, Omerovic E, Fröbert O et al.
NEJM (2017) Online 21 September. Original Article.

Childhood onset inflammatory bowel disease and risk of cancer: a Swedish nationwide cohort study 1964-2014
Olén O, Askling J, Sachs MC, Frumento P, Neovius M, Smedby KE, Ekbom A, Malmborg P, Ludvigsson JF
BMJ (2017) Online 20 September. Research.
På KI Nyheter: Inflammatorisk tarmsjukdom i barndomen kopplat till ökad cancerrisk

Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke
Søndergaard L, Kasner SE, Rhodes JF, Andersen G, Iversen HK, Nielsen-Kudsk JE, Settergren M, Sjöstrand C, Roine RO, Hildick-Smith D, Spence JD,  Thomassen L, for the Gore REDUCE Clinical Study Investigators
NEJM (2017) Online 14 September. Original Article. 

Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial
Holman RR, Coleman RL, Chan JCN et al
Lancet Diabetes & Endocrinology (2017) Online 13 September. Article.

Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation
Riffelmacher T, Clarke A, Richter FC, Stranks A, Pandey S, Danielli S, Hublitz P, Yu Z, Johnson E, Schwerd T, McCullagh J, Uhlig H, Jacobsen SEW, Simon AK.
Immunity (2017) Online 12 September. Article.

Association Between Laparoscopic Antireflux Surgery and Recurrence of Gastroesophageal Reflux
Maret-Ouda J, Wahlin K, El-Serag HB, Lagergren J
JAMA (2017) Online 12 September. Original Investigation.
På KI Nyheter: Unga män som opereras mot reflux får sällan återfall

Oxygen Therapy in Suspected Acute Myocardial Infarction
Hofmann R, James SK, Jernberg T et al.
NEJM (2017) Online 28 August. Original Article.
På KI Nyheter: Syrgasbehandling vid hjärtinfarkt saknar effekt

PCI Versus CABG in Patients With Type 1 Diabetes and Multivessel Disease
Nyström T, Sartipy U, Franzén S, Eliasson B, Gudbjörnsdottir S, Miftaraj M, Lagerqvist B, Svensson A-M, och Holzmann MJ.
JACC (2017) Online 26 August. Article.
På KI Nyheter: Kranskärlskirurgi effektivt vid typ 1-diabetes

Notch Signaling in Development, Tissue Homeostasis, and Disease
Siebel C, Lendahl U
Physiological Reviews (2017) Online 9 August. Review.  

Distrust in the End-Of-Life Care Provided to a Parent and Long-Term Negative Outcomes Among Bereaved Adolescents: A Population-Based Survey Study 
Beernaert K, Kreicbergs U, Furst CJ, Nyberg T, Steineck G, Bylund-Grenklo T, Journal of Clinical Oncology (2017), Original Report.

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
Alberts R, de Vries EMG, Goode EC et al.
Gut (2017) Online 4 August. Original Article.

IgG Endopeptidase in Highly Sensitized Patients Undergoing Transplantation
Jordan SC, Lorant T, Choi J, et al, NEJM (2017), original article

Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis
Birkeland KI, Jørgensen ME, Carstensen B et al, The Lancet Diabetes & Endocrinology (2017), Online 3 August, Article.

Increased Total mtDNA Copy Number Cures Male Infertility Despite Unaltered mtDNA Mutation Load
Jiang M, Eino T, Kauppila S et al, Cell Metabolism (2017), Online 1 August. Short Article.

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